Uninformative polymorphisms bias genome scans for signatures of selection
نویسندگان
چکیده
منابع مشابه
A genome-wide scan to detect signatures of recent selection in Australian Merino sheep
Domestication and selection are processes that conserve the pattern of genetic diversities between and within populations. Identification of genomic regions that are targets of selection for phenotypic traits is one of the main aims of research in animal genetics. An approach for identifying divergently selected regions of the genome is to compare FST values among loci to estimate the genetic v...
متن کاملGenome‐wide scans between two honeybee populations reveal putative signatures of human‐mediated selection
Human-mediated selection has left signatures in the genomes of many domesticated animals, including the European dark honeybee, Apis mellifera mellifera, which has been selected by apiculturists for centuries. Using whole-genome sequence information, we investigated selection signatures in spatially separated honeybee subpopulations (Switzerland, n = 39 and France, n = 17). Three different test...
متن کاملGenome-wide scans for footprints of natural selection
Detecting recent selected 'genomic footprints' applies directly to the discovery of disease genes and in the imputation of the formative events that molded modern population genetic structure. The imprints of historic selection/adaptation episodes left in human and animal genomes allow one to interpret modern and ancestral gene origins and modifications. Current approaches to reveal selected re...
متن کاملControlling false discoveries in genome scans for selection.
Population differentiation (PD) and ecological association (EA) tests have recently emerged as prominent statistical methods to investigate signatures of local adaptation using population genomic data. Based on statistical models, these genomewide testing procedures have attracted considerable attention as tools to identify loci potentially targeted by natural selection. An important issue with...
متن کاملwhole-genome scan of eight iranian native cattle breeds to detect selection signatures.
this study aimed to identify genes that show signatures of selection for mutations in iranian native cattle breeds. the data consisted of genotypes for ~777962 snp markers of 90 animals from eight iranian native cattle breeds distributing over the country. therefore, the aim was to identifying divergently selected regions of the genome. study of population differentiation across the genome usin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Evolutionary Biology
سال: 2012
ISSN: 1471-2148
DOI: 10.1186/1471-2148-12-94